Biopharmaceutical Technology – MSc/Postgrad Diploma

Biosynthesis, composition, higher order structure and post-translational modification of protein biopharmaceutical products are reviewed within this module, along with stabilising forces which lead to correct folding and biological functionality. Various classes of protein biopharmaceuticals currently in use are investigated along with typical biological targets.

An authoritative resource on how biological drug products are characterised, using instrumental and molecular methods, is provided by this module.

Focusing on the skills needed to develop a research project (semester 3), this module provides tools to further career development and research capability. The module has three components: Research Methods, Professional and Transferable Skills and Career Development and Continuous Professional Development (CPD).

Traditional and current methods involved in developing cell lines and their growth in culture are explored within this module, while engaging with the more novel methods to improve biopharmaceutical production. Providing knowledge and skills required to develop and grow mammalian cells in vitro, the module focuses on culture optimisation, with a view to scale up for industrial protein production.

Concepts of both Lean and Six Sigma are addressed by this module. The aim of Lean methodologies is to reduce waste, the goal of Six Sigma is to reduce variation for optimal quality control. The Lean Six Sigma (LSS) discipline blends these two approaches. The module content is aligned with the American Society of Quality (ASQ) Lean Six Sigma Green Belt. Green belts are skilled team players, their aim is to improve process quality, helping to bridge the gap between Six Sigma theory and real-world application.

This year long-lab-based module provides practical training in a range of upstream and downstream biopharmaceutical processes, including CHO cell culture, cell line development, protein recovery and analysis. Development of teamwork, troubleshooting and critical thinking skills in areas relevant to the biopharmaceutical industry is a key focus. An industry training opportunity at the National Institute for Bioprocessing Research & Training (NIBRT) occurs in semester II. On completion students can apply for a TUS digital badge to highlight this training on CV/LinkedIn profiles.

This year long-lab-based module provides practical training in a range of upstream and downstream biopharmaceutical processes, including CHO cell culture, cell line development, protein recovery and analysis. Development of teamwork, troubleshooting and critical thinking skills in areas relevant to the biopharmaceutical industry is a key focus. An industry training opportunity at the National Institute for Bioprocessing Research & Training (NIBRT) occurs in semester II. On completion students can apply for a TUS digital badge to highlight this training on CV/LinkedIn profiles.

Immunobiologics as protein therapeutics is explored within this module, including their development, toxicity, and regulation, and the evolution of biosimilars. More novel immune based therapeutics are investigated, including cells and nucleic acids, highlighting the ever-expanding potential of the immune system in disease treatment and prevention.

A unique feature of the module is the incorporation of guest speakers from the Biopharmaceutical industry, to address current trends in biopharmaceutical manufacturing, including real life scenarios. Career focused talks by visiting Masters alumni and TUS academic staff/postgraduate researchers take place throughout the semester.

This module focuses on upstream and downstream processes currently used in the industrial manufacture of biopharmaceuticals, with a particular emphasis on mammalian cell lines producing therapeutic biologics.

The critical importance of consistent implementation of Quality By Design (QBD) concepts for effective long term project management is emphasised within this module. A high-level overview of the requirements of Quality Control (QC) and Quality Systems Management (QSM) is provided, with the appropriate tools to implement QBD and optimise manufacturing processes for biotechnological/biological entities.

The Research Project (30 credits), a crucial element of the M.Sc in Biopharmaceutical Technology, is carried out in semester 3. Preparatory work for projects begins in September, through the module Research Methods and Professional Development Skills, where research titles/topics are assigned, research questions are defined, and project plans developed. A focused literature review is carried out in Semester 2 and laboratory-based research is carried out under supervision in semester 3. This research opportunity enables students to adapt various techniques to overcome research challenges, and to gain experience and develop skills in the analysis and interpretation of data. Research findings are presented in written (thesis) and oral format at the beginning of August